Article

Identification of Cancer–associated Metabolic Vulnerabilities by Modeling Multi-objective Optimality in Metabolism

2017-10-04

Abstract excerpt

Computational modeling of the genome-wide metabolic network is essential for designing new therapeutics targeting cancer-associated metabolic disorder, which is a hallmark of human malignancies. However, previous studies generally assumed that metabolic fluxes of cancer cells are subjected to the maximization of biomass production, despite the wide existence of trade-offs among multiple metabolic objectives. To ad...

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Literature Corpus work: 68f4b793-1f14-5399-b10c-42639e749996
DOI: 10.1101/198333

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