Article
CD8+ Tregs revisited: A heterogeneous population with different phenotypes and properties.
European journal of immunology - 1 Mar 2021
Niederlova Veronika, Tsyklauri Oksana, Chadimova Tereza, Stepanek Ondrej
Abstract excerpt
Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ counterparts are still controversial in many aspects including their phenotypic identity and their mechanisms of suppression. Because of these controversies and because of only a limited number of studies documenting the immunoregulatory...
Topics
- Animals
- CD28 Antigens
- CD8-Positive T-Lymphocytes
- Humans
- Immune Tolerance
- Phenotype
- T-Lymphocyte Subsets
- T-Lymphocytes, Regulatory