Article

IRES-TrAPPr reveals novel insights into viral and cellular mRNA translation

2026-05-09

Abstract excerpt

Ribosome recruitment to human mRNAs is thought to occur primarily via cap-dependent initiation (CDI). This process is suppressed during a variety of cellular stresses, including viral infection, suggesting stress-response genes and viral mRNAs use alternative mechanisms to initiate translation. Indeed, many viruses recruit ribosomes directly via Internal Ribosome Entry Sites (IRESes). Hundreds of human mRNAs have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 148dc93c-d6a1-5113-90fc-320f57e02c88
DOI: 10.64898/2026.05.06.723280

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IRES-TrAPPr reveals novel insights into viral and cellular mRNA translationDOI 10.64898/2026.05.06.723280Read

Sequence features of viral and human Internal Ribosome Entry Sites predictive of their activitySemantic proximity Read

A New Way to Discover IRESs in Pathology or Stress Conditions? Harnessing Latest High-Throughput Technologies.Semantic proximity Read

IRES Trans-Acting Factors, Key Actors of the Stress ResponseSemantic proximity Read

Systematic discovery of cap-independent translation sequences in human and viral genomesSemantic proximity Read

Viral Internal Ribosome Entry Site Elements: Novel Ribosome-RNA Complexes and Roles in Viral PathogenesisSemantic proximity Read

Structured elements drive extensive circular RNA translation.Semantic proximity Read

Synthetic circRNAs employ IRES activity for translation in cells and in cell-free translation systemsSemantic proximity Read

IRES Trans-Acting Factors, Key Actors of the Stress ResponseSemantic proximity Read

IRESbase: A Comprehensive Database of Experimentally Validated Internal Ribosome Entry SitesSemantic proximity Read

Cellular IRES-mediated translationSemantic proximity Read

The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic interventionSemantic proximity Read

Exploring Internal Ribosome Entry Sites as Therapeutic TargetsSemantic proximity Read