Article
A New Way to Discover IRESs in Pathology or Stress Conditions? Harnessing Latest High-Throughput Technologies.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Mar 2020
Wang Lei-Yun, Cui Jia-Jia, Guo Cheng-Xian, Yin Ji-Ye
Abstract excerpt
The cellular internal ribosomal entry site (IRES) is one of the most important elements to mediate cap-independent translational initiation, especially under conditions of stress and pathology. However, a high-throughput method to discover IRESs in these conditions is still lacking. Here, a possible way IRES long-read sequencing based on the latest high-throughput technologies is proposed to solve this problem....
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