Article

RIG-I activation primes and trains innate antiviral immune memory

2022-10-28

Abstract excerpt

Adaptive processes of the innate immune system, known as trained immunity (TI), are critical to human health and disease, yet they have not been systematically investigated downstream of antiviral sensing. Here, we elucidate the potential of the antiviral cytosolic RNA receptor retinoic acid-inducible gene I (RIG-I) to train, prime and tolerize the innate immune system. Using a specific RIG-I agonist, we observed...

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Literature Corpus work: 14625615-ca69-5cb2-885d-5ba398f47e8f
DOI: 10.1101/2022.10.27.514004

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