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RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection

13 Aug 2019

Abstract excerpt

RIG-I-Like Receptors (RLRs) RIG-I, MDA5, and LGP2, are vital pathogen recognition receptors in the defense against RNA viruses. West Nile Virus (WNV) infections continue to grow in the US. Here, we use a systems biology approach to define the contributions of each RLR in the innate immune response to WNV. Genome-wide RNAseq and bioinformatics analyses of macrophages from mice lacking either RLR reveal that the...

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PMID: 31409781
DOI: 10.1038/s41467-019-11250-5

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