Article
RIG-I-Like Receptors and Type I Interferonopathies.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 May 2017
Kato Hiroki, Oh Seong-Wook, Fujita Takashi
Abstract excerpt
Type I interferon (IFN) production by the proper activation of nucleic acid sensors is essential for hosts to eliminate invading viruses. Among these sensors, RIG-I-like receptors (RLRs) are well-known viral RNA sensors in the cytoplasm that recognize the nonself signatures of viral RNAs to trigger IFN responses. Recent accumulating evidence has clarified that some specific and atypical self-RNAs also cause...
Topics
- Animals
- Autoimmune Diseases
- DEAD Box Protein 58
- Humans
- Interferon Type I
- Interferon-Induced Helicase, IFIH1
- Polymorphism, Single Nucleotide
- Receptors, Immunologic