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Article

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

Molecular and cellular biology - 1 Jul 2005

You Zhongsheng, Chahwan Charly, Bailis Julie, Hunter Tony, Russell Paul

Abstract excerpt

ATM has a central role in controlling the cellular responses to DNA damage. It and other phosphoinositide 3-kinase-related kinases (PIKKs) have giant helical HEAT repeat domains in their amino-terminal regions. The functions of these domains in PIKKs are not well understood. ATM activation in response to DNA damage appears to be regulated by the Mre11-Rad50-Nbs1 (MRN) complex, although the exact functional...

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Source

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Identifiers

PMID: 15964794
DOI: 10.1128/MCB.25.13.5363-5379.2005
PMCID: PMC1156989

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.PMID 15964794Read ↗

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The NBS1-ATM Connection RevisitedSemantic proximity Read ↗

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Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Semantic proximity Read ↗

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