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Article

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.

Science (New York, N.Y.) - 2 Apr 2004

Lee Ji-Hoon, Paull Tanya T

Abstract excerpt

The complex containing the Mre11, Rad50, and Nbs1 proteins (MRN) is essential for the cellular response to DNA double-strand breaks, integrating DNA repair with the activation of checkpoint signaling through the protein kinase ATM (ataxia telangiectasia mutated). We demonstrate that MRN stimulates the kinase activity of ATM in vitro toward its substrates p53, Chk2, and histone H2AX. MRN makes multiple contacts...

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Share to Acid Anhydride Hydrolases
Share to Ataxia Telangiectasia
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Repair Enzymes

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Source

Identifiers

PMID: 15064416
DOI: 10.1126/science.1091496

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.PMID 15064416Read ↗

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair.Semantic proximity Read ↗

Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.Semantic proximity Read ↗

Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.Semantic proximity Read ↗

Competition between NBS1 and ATMIN Controls ATM Signaling Pathway ChoiceSemantic proximity Read ↗

Structure of the human ATM kinase and mechanism of Nbs1 bindingSemantic proximity Read ↗

Structure of the human ATM kinase and mechanism of Nbs1 binding.Semantic proximity Read ↗

Rad50 depletion impacts upon ATR-dependent DNA damage responses.Semantic proximity Read ↗

Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.Semantic proximity Read ↗

The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks.Semantic proximity Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

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