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Article

Pitchfork regulates primary cilia disassembly and left-right asymmetry.

Developmental cell - 20 Jul 2010

Kinzel Doris, Boldt Karsten, Davis Erica E, Burtscher Ingo, Trümbach Dietrich, Diplas Bill, Attié-Bitach Tania, Wurst Wolfgang, Katsanis Nicholas, Ueffing Marius, Lickert Heiko

Abstract excerpt

A variety of developmental disorders have been associated with ciliary defects, yet the controls that govern cilia disassembly are largely unknown. Here we report a mouse embryonic node gene, which we named Pitchfork (Pifo). Pifo associates with ciliary targeting complexes and accumulates at the basal body during cilia disassembly. Haploinsufficiency causes a unique node cilia duplication phenotype, left-right...

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Identifiers

PMID: 20643351
DOI: 10.1016/j.devcel.2010.06.005
PMCID: PMC3671612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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