Article
A Zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals Its Specific Role in Laterality Organ Function.
Human mutation - 1 Feb 2016
Noël Emily S, Momenah Tarek S, Al-Dagriri Khalid, Al-Suwaid Abdulrahman, Al-Shahrani Safar, Jiang Hui, Willekers Sven, Oostveen Yara Y, Chocron Sonja, Postma Alex V, Bhuiyan Zahurul A, Bakkers Jeroen
Abstract excerpt
Establishing correct left-right asymmetry during embryonic development is crucial for proper asymmetric positioning of the organs. Congenital heart defects, such as dextrocardia, transposition of the arteries, and inflow or outflow tract malformations, comprise some of the most common birth defects and may be attributed to incorrect establishment of body laterality. Here, we identify new patients with...
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