Article

Myeloid-derived β-hexosaminidase is essential for neuronal health and lysosome function: implications for Sandhoff disease

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Lysosomal storage disorders (LSDs) are a large disease class involving lysosomal dysfunction, often resulting in neurodegeneration. Sandhoff disease (SD) is an LSD caused by a deficiency in the β subunit of the β-hexosaminidase enzyme ( Hexb ). Although Hexb expression in the brain is specific to microglia, SD primarily affects neurons. To understand how a microglial gene is involved in mainta...

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Literature Corpus work: 2c23f684-469f-5675-815d-f642ea2ffd8e
DOI: 10.1101/2024.10.21.619538

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