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Critical role of the RpoE stress response pathway in polymyxin resistance of Escherichia coli

20 Jan 2023

Abstract excerpt

OBJECTIVES: Polymyxins, including colistin, are the drugs of last resort to treat MDR bacterial infections in humans. In-depth understanding of the molecular basis and regulation of polymyxin resistance would provide new therapeutic opportunities to combat increasing polymyxin resistance. Here we aimed to identify novel targets that are crucial for polymyxin resistance using Escherichia coli BL21(DE3), a unique...

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PMID: 36658759
DOI: 10.1093/jac/dkad003

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