Article

Mutations in <i>pmrB</i> confer cross-resistance to the LptD inhibitor POL7080 and colistin in <i>Pseudomonas aeruginosa</i>

2019-03-08

Abstract excerpt

Pseudomonas aeruginosa is a major bacterial pathogen for which there is rising antibiotic resistance. We evaluated the resistance mechanisms of P. aeruginosa against POL7080, a species-specific, first-in-class antibiotic in phase 3 clinical trials targeting the lipopolysaccharide transport protein LptD. We found resistance mutations in the two-component regulator pmrB . Genome-wide transcriptomics and confocal m...

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Literature Corpus work: 1771a859-9598-5818-a36b-691ad0a848d1
DOI: 10.1101/571224

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