Article

Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human Cells

2020-03-20

Abstract excerpt

The most rapid path to discovering treatment options for the novel coronavirus SARS-CoV-2 is to find existing medications that are active against the virus. We have focused on identifying repurposing candidates for the transmembrane serine protease family member II (TMPRSS2), which is critical for entry of coronaviruses into cells. Using known 3D structures of close homologs, we created seven homology models. We a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a20495fe-17d0-5b38-affd-d7912a7fc331
DOI: 10.26434/chemrxiv.12009582.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human CellsDOI 10.26434/chemrxiv.12009582.v1Read

Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studiesSemantic proximity Read

Molecular Modeling Targeting Transmembrane Serine Protease 2 (TMPRSS2) as an Alternative Drug Target Against CoronavirusesSemantic proximity Read

Virtual drug repurposing study against SARS-CoV-2 TMPRSS2 targetSemantic proximity Read

Structure, activity and inhibition of human TMPRSS2, a protease implicated in SARS-CoV-2 activationSemantic proximity Read

An Overview of SARS-CoV-2 Potential Targets, Inhibitors, and Computational Insights to Enrich the Promising Treatment StrategiesSemantic proximity Read

Homology Modeling and Docking Studies of TMPRSS2 with Experimentally Known Inhibitors Camostat Mesylate, Nafamostat and Bromhexine Hydrochloride to Control SARS-Coronavirus-2Semantic proximity Read

Structural Analysis of Experimental Drugs Binding to the COVID-19 Target TMPRSS2Semantic proximity Read

Virtual screening FDA approved drugs against multiple targets of SARS‐CoV‐2Semantic proximity Read

Integrated Docking and Enhanced Sampling Based Selection of Repurposing Drugs for SARS-CoV-2 by Targeting Host Dependent FactorsSemantic proximity Read

A SARS-CoV-2 protein interaction map reveals targets for drug repurposingSemantic proximity Read

In Silico Drug Discovery: The Next Frontier in the Fight Against SARS-CoV-2Semantic proximity Read

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screeningSemantic proximity Read