Article

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

2020-08-06

Abstract excerpt

<h4>ABSTRACT</h4> The number of new cases world-wide for the COVID-19 disease is increasing dramatically, while efforts to contain Severe Acute Respiratory Syndrome Coronavirus 2 is producing varied results in different countries. There are three key SARS-CoV-2 enzymes potentially targetable with antivirals: papain-like protease (PLpro), main protease (Mpro), and RNA-dependent RNA polymerase. Of these, PLpro is a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 54460de7-4537-5229-a057-de906baeffd4
DOI: 10.1101/2020.08.06.240192

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitorsDOI 10.1101/2020.08.06.240192Read

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.Semantic proximity Read

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistanceSemantic proximity Read

Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19Semantic proximity Read

Minireview of progress in the structural study of SARS-CoV-2 proteinsSemantic proximity Read

Structural basis for the inhibition of coronaviral main proteases by PF-00835231Semantic proximity Read

Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug bindingSemantic proximity Read

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2Semantic proximity Read

Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2Semantic proximity Read

Structural basis for the inhibition of coronaviral main proteases by PF-00835231.Semantic proximity Read

Characterization and Inhibition of the Main Protease of Severe Acute Respiratory Syndrome CoronavirusSemantic proximity Read

3-Chymotrypsin-like Protease (3CLpro): Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical TrialsSemantic proximity Read

Papain-Like Proteases as Coronaviral Drug Targets: Current Inhibitors, Opportunities, and LimitationsSemantic proximity Read