Article

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

2021-04-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin secreting beta cells, causing diabetes. In human, homozygous mutations of NEUROG3 manifest with neonatal or childhood diabetes. Despite this critical role in islet cell development, the precise function and downstream genetic programs regulated directly by NEUROG3 re...

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Literature Corpus work: 141f49bd-ce6e-529a-be60-607f50771a4c
DOI: 10.1101/2021.04.14.439685

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