Article

NGN3 oscillatory expression controls the timing of human pancreatic endocrine differentiation

2024-01-11

Abstract excerpt

<h4>Summary</h4> Understanding protein expression dynamics is crucial for the mechanistic understanding of cell differentiation. We investigate the dynamics of NGN3, a transcription factor critical for pancreatic endocrine development, including their function and decoding mechanisms. A knock-in endogenous reporter shows that the expression of NGN3 protein oscillates with a 13-hour periodicity in human iPS-derive...

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Literature Corpus work: dd8dacf8-67bc-54e1-9724-fec685935435
DOI: 10.1101/2024.01.10.574974

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