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The Basic Helix-Loop-Helix Transcription Factor NEUROG3 Is Required for Development of the Human Endocrine Pancreas.

Diabetes - 1 Jul 2015

McGrath Patrick S, Watson Carey L, Ingram Cameron, Helmrath Michael A, Wells James M

Abstract excerpt

Neurogenin3 (NEUROG3) is a basic helix-loop-helix transcription factor required for development of the endocrine pancreas in mice. In contrast, humans with NEUROG3 mutations are born with endocrine pancreas function, calling into question whether NEUROG3 is required for human endocrine pancreas development. To test this directly, we generated human embryonic stem cell (hESC) lines where both alleles of NEUROG3...

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Source

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Identifiers

PMID: 25650326
DOI: 10.2337/db14-1412
PMCID: PMC4477351

Genes

NEUROG3
PDX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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