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Article

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

2 Aug 2021

Abstract excerpt

OBJECTIVE: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEUROG3 manifest with neonatal or childhood diabetes. Despite this critical role in islet cell development, the precise function of and downstream genetic programs regulated directly by NEUROG3...

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PMID: 34352411
DOI: 10.1016/j.molmet.2021.101313

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