Article
Neurogenin3 Cooperates with Foxa2 to Autoactivate Its Own Expression
8 Mar 2013
Abstract excerpt
The transcription factor Neurogenin3 functions as a master regulator of endocrine pancreas formation, and its deficiency leads to the development of diabetes in humans and mice. In the embryonic pancreas, Neurogenin3 is transiently expressed at high levels for a narrow time window to initiate endocrine differentiation in scattered progenitor cells. The mechanisms controlling these rapid and robust changes in...
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