Article

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair

2021-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic mutations in the BRCA2 tumor suppressor gene predispose to breast, ovarian, pancreatic, prostate, and other cancers. BRCA2 maintains genome stability through homology-directed repair (HDR) of DNA double-strand breaks (DSBs) and replication fork protection. Nonsense or frameshift mutations leading to truncation of the BRCA2 protein are typically considered pathogenic, however, missense...

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Literature Corpus work: 10621a50-1875-56b7-9fef-371d3b969291
DOI: 10.1101/2021.09.24.461749

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