Homologous repair of DNA damage and tumorigenesis: the BRCA connection.

doi:10.1038/sj.onc.1206176

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Article

Homologous repair of DNA damage and tumorigenesis: the BRCA connection.

Oncogene - 16 Dec 2002

Jasin Maria

Abstract excerpt

Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such damage as chromosomal double-strand breaks. Cells mutated for the genes involved in the hereditary breast and ovarian cancer susceptibility syndromes, i.e. BRCA1 and BRCA2, show defects in DNA repair by homologous recombination, implicating this repair pathway in protecting individuals...

Topics

Amino Acid Sequence
Animals
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Carrier Proteins
Conserved Sequence
DNA Damage
DNA Repair
DNA-Binding Proteins
Female
Humans
Mutation
Neoplasms
Ovarian Neoplasms
Rad51 Recombinase
Recombination, Genetic
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 12483514
DOI: 10.1038/sj.onc.1206176

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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