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Article

Homologous repair of DNA damage and tumorigenesis: the BRCA connection.

Oncogene - 16 Dec 2002

Jasin Maria

Abstract excerpt

Homologous recombination has been recognized in recent years to be an important DNA repair pathway in mammalian cells, for such damage as chromosomal double-strand breaks. Cells mutated for the genes involved in the hereditary breast and ovarian cancer susceptibility syndromes, i.e. BRCA1 and BRCA2, show defects in DNA repair by homologous recombination, implicating this repair pathway in protecting individuals...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12483514
DOI: 10.1038/sj.onc.1206176

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homologous repair of DNA damage and tumorigenesis: the BRCA connection.PMID 12483514Read ↗

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Hereditary Breast and Ovarian Cancer Syndrome: Moving Beyond BRCA1 and BRCA2Semantic proximity Read ↗

In brief: BRCA1 and BRCA2.Semantic proximity Read ↗

The relationship between the roles of BRCA genes in DNA repair and cancer predisposition.Semantic proximity Read ↗

Defects in homologous recombination repair behind the human diseases: FA and HBOCSemantic proximity Read ↗

Cancer susceptibility and the functions of BRCA1 and BRCA2.Semantic proximity Read ↗

BRCA1/2 signaling and homologous recombination deficiency in breast and ovarian cancer.Semantic proximity Read ↗

Homologous Recombination Deficiencies and Hereditary Tumors.Semantic proximity Read ↗

BRCA Gene Structure and Function in Tumor SuppressionSemantic proximity Read ↗

Molecular functions of BRCA1 in the DNA damage response.Semantic proximity Read ↗

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