Article

Multimodal analysis of rare BARD1 missense variant suggests its pathogenicity is conditional

2025-09-24

Abstract excerpt

<title>Abstract</title> <p>Hereditary breast cancer involves multiple risk genes, including <italic>BARD1</italic>, which confers low to moderate risk and is associated with triple-negative breast cancer (TNBC). We report a proband with a primary ER+/PR+/HER2- breast cancer which recurred unilaterally as a TNBC and who later developed endometrial cancer. Clinical germline testing revealed a rare <italic>BARD1</it...

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Literature Corpus work: 28c0e3c0-cd9f-5e2e-8c32-f8ad57e6f132
DOI: 10.21203/rs.3.rs-7595877/v1

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