Article
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.
Proceedings of the National Academy of Sciences of the United States of America - 12 Apr 2005
Rashid Shirya, Curtis David E, Garuti Rita, Anderson Norma N, Bashmakov Yuriy, Ho Y K, Hammer Robert E, Moon Young-Ah, Horton Jay D
Abstract excerpt
PCSK9 encodes proprotein convertase subtilisin/kexin type 9a (PCSK9), a member of the proteinase K subfamily of subtilases. Missense mutations in PCSK9 cause an autosomal dominant form of hypercholesterolemia in humans, likely due to a gain-of-function mechanism because overexpression of either WT or mutant PCSK9 reduces hepatic LDL receptor protein (LDLR) in mice. Here, we show that livers of knockout mice...
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