Article
Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma
2018-10-30
Abstract excerpt
Continual evolution of cancer makes it challenging to predict clinical outcomes. Highly varied and unpredictable patient outcomes in esophageal adenocarcinoma (EAC) prompted us to question the pattern and timing of metastatic spread. Whole genome sequencing and phylogenetic analysis of 396 samples across 18 EAC cases demonstrated a stellate pattern on the phylogenetic trees in 90% cases. The age-dependent trinucle...
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Identifiers and source
- Literature Corpus work
- 14133d61-c217-5a7d-be05-31300e53d556
- DOI
- 10.1101/454306