Article
Reconstructing metastatic seeding patterns of human cancers.
Nature communications - 31 Jan 2017
Reiter Johannes G, Makohon-Moore Alvin P, Gerold Jeffrey M, Bozic Ivana, Chatterjee Krishnendu, Iacobuzio-Donahue Christine A, Vogelstein Bert, Nowak Martin A
Abstract excerpt
Reconstructing the evolutionary history of metastases is critical for understanding their basic biological principles and has profound clinical implications. Genome-wide sequencing data has enabled modern phylogenomic methods to accurately dissect subclones and their phylogenies from noisy and impure bulk tumour samples at unprecedented depth. However, existing methods are not designed to infer metastatic seeding...
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