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Article

Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma.

Nature genetics - 1 Dec 2016

Hao Jia-Jie, Lin De-Chen, Dinh Huy Q, Mayakonda Anand, Jiang Yan-Yi, Chang Chen, Jiang Ye, Lu Chen-Chen, Shi Zhi-Zhou, Xu Xin, Zhang Yu, Cai Yan, Wang Jin-Wu, Zhan Qi-Min, Wei Wen-Qiang, Berman Benjamin P, Wang Ming-Rong, Koeffler H Phillip

Abstract excerpt

Esophageal squamous cell carcinoma (ESCC) is among the most common malignancies, but little is known about its spatial intratumoral heterogeneity (ITH) and temporal clonal evolutionary processes. To address this, we performed multiregion whole-exome sequencing on 51 tumor regions from 13 ESCC cases and multiregion global methylation profiling for 3 of these 13 cases. We found an average of 35.8% heterogeneous...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27749841
DOI: 10.1038/ng.3683
PMCID: PMC5127772

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MTOR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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