Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lymph Node Metastases in Colon Cancer Are Polyclonal.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2018

Ulintz Peter J, Greenson Joel K, Wu Rong, Fearon Eric R, Hardiman Karin M

Abstract excerpt

Purpose: Recent studies have highlighted the existence of subclones in tumors. Lymph nodes are generally the first location of metastasis for most solid epithelial tumors, including colorectal cancer. We sought to understand the genetic origin of lymph node metastasis in colorectal cancer by evaluating the relationship between colorectal cancer subclones present in primary tumors and lymph nodes.Experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clonal Evolution
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Copy Number Variations

Share to Genetic Heterogeneity

Share to Lymph Nodes

Share to Lymphatic Metastasis

Share to Neoplasm Staging

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 29203589
DOI: 10.1158/1078-0432.CCR-17-1425
PMCID: PMC5932232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lymph Node Metastases in Colon Cancer Are Polyclonal.PMID 29203589Read ↗

Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis.Semantic proximity Read ↗

Origins of lymphatic and distant metastases in human colorectal cancerSemantic proximity Read ↗

The clonal heterogeneity of colon cancer with liver metastases.Semantic proximity Read ↗

Genomic evolution and diverse models of systemic metastases in colorectal cancer.Semantic proximity Read ↗

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases.Semantic proximity Read ↗

Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis.Semantic proximity Read ↗

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastasesSemantic proximity Read ↗

Defining the “Metastasome”: Perspectives from the genome and molecular landscape in colorectal cancer for metastasis evolution and clinical consequencesSemantic proximity Read ↗

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.Semantic proximity Read ↗

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer.Semantic proximity Read ↗

Whole exome and transcriptome sequencing reveal clonal evolution and exhibit immune-related features in metastatic colorectal tumorsSemantic proximity Read ↗

Molecular differences between lymph nodes and distant metastases compared with primaries in colorectal cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.