Article
Genomics and phenomics of body mass index reveals a complex disease network.
Nature communications - 29 Dec 2022
Huang Jie, Huffman Jennifer E, Huang Yunfeng, Do Valle Ítalo, Assimes Themistocles L, Raghavan Sridharan, Voight Benjamin F, Liu Chang, Barabási Albert-László, Huang Rose D L, Hui Qin, Nguyen Xuan-Mai T, Ho Yuk-Lam, Djousse Luc, Lynch Julie A, Vujkovic Marijana, Tcheandjieu Catherine, Tang Hua, Damrauer Scott M, Reaven Peter D, Miller Donald, Phillips Lawrence S, Ng Maggie C Y, Graff Mariaelisa, Haiman Christopher A, Loos Ruth J F, North Kari E, Yengo Loic, Smith George Davey, Saleheen Danish, Gaziano J Michael, Rader Daniel J, Tsao Philip S, Cho Kelly, Chang Kyong-Mi, Wilson Peter W F, Sun Yan V, O'Donnell Christopher J
Abstract excerpt
Elevated body mass index (BMI) is heritable and associated with many health conditions that impact morbidity and mortality. The study of the genetic association of BMI across a broad range of common disease conditions offers the opportunity to extend current knowledge regarding the breadth and depth of adiposity-related diseases. We identify 906 (364 novel) and 41 (6 novel) genome-wide significant loci for BMI...
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