Article
Δlpp mutant E. coli reduces lipid content in Caenorhabditis elegans via phosphatidylglycerol-mediated inhibition of fatty acid biosynthesis.
mSystems - 21 Jul 2026
Zhou Dianshuang, Tang Liwei, Ni Mengdie, Yang Wen, Wang Xiangming, Li Ying, Zhu Zuobin
Abstract excerpt
Although the gut microbiota is known to influence host metabolism, how specific bacterial genetic mutations modulate lipid metabolism remains unclear. In this study, we integrated in vivo lipid visualization, whole-transcriptome RNA sequencing, and lipidomics to investigate the effects of the Δlpp mutant of Escherichia coli on Caenorhabditis elegans (C. elegans). Our results demonstrated that the Δlpp mutant...
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