Article

PGC-1α drives small cell neuroendocrine cancer progression towards an ASCL1-expressing subtype with increased mitochondrial capacity

2024-04-13

Abstract excerpt

<h4>ABSTRACT</h4> Adenocarcinomas from multiple tissues can evolve into lethal, treatment-resistant small cell neuroendocrine (SCN) cancers comprising multiple subtypes with poorly defined metabolic characteristics. The role of metabolism in directly driving subtype determination remains unclear. Through bioinformatics analyses of thousands of patient tumors, we identified enhanced PGC-1α—a potent regulator of ox...

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Literature Corpus work: 13b79428-e692-5284-b72b-c7af8e6bee6c
DOI: 10.1101/2024.04.09.588489

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