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Article

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis

23 Mar 2018

Abstract excerpt

Metabolic reprogramming confers cancer cells the ability to grow and survive under nutrient-depleted or stressful microenvironments. The amplification of oncogenes, the loss of tumor suppressors, as well as context- and lineage-specific determinants can converge and profoundly affect the metabolic status of cancer cells. Cumulating evidences suggest that highly glycolytic cells under the influence of oncogenes...

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PMID: 29629336
DOI: 10.3389/fonc.2018.00075

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