Article

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

2025-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Mesenchymal stem cell extracellular vesicles (MSC EVs) have been widely studied for regenerative medicine and tissue repair applications. However, clinical translation of EV therapeutics has been hampered by low potency and lack of scalable production strategies. This work aims to develop a novel approach that exploits the mechanosensitivity of MSCs to enhance EV potency in the context of enhanc...

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Literature Corpus work: 78b92d74-784b-5d52-b5d7-e56f7a5a0e7e
DOI: 10.1101/2025.08.12.669872

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