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Article

Suspension culture improves iPSC expansion and pluripotency phenotype.

Stem cell research & therapy - 6 Jun 2023

Cuesta-Gomez Nerea, Verhoeff Kevin, Dadheech Nidheesh, Dang Tiffany, Jasra Ila Tewari, de Leon Mario Bermudez, Pawlick Rena, Marfil-Garza Braulio, Anwar Perveen, Razavy Haide, Zapata-Morin Patricio Adrián, Jickling Glen, Thiesen Aducio, O'Gorman Doug, Kallos Michael S, Shapiro A M James

Abstract excerpt

BACKGROUND: Induced pluripotent stem cells (iPSCs) offer potential to revolutionize regenerative medicine as a renewable source for islets, dopaminergic neurons, retinal cells, and cardiomyocytes. However, translation of these regenerative cell therapies requires cost-efficient mass manufacturing of high-quality human iPSCs. This study presents an improved three-dimensional Vertical-Wheel® bioreactor (3D...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37280707
DOI: 10.1186/s13287-023-03382-9
PMCID: PMC10245469

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