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Article

Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy.

Scientific reports - 5 May 2020

Gan Peiheng, Patterson Michaela, Watanabe Hirofumi, Wang Kristy, Edmonds Reilly A, Reinholdt Laura G, Sucov Henry M

Abstract excerpt

Most mouse cardiomyocytes (CMs) become multinucleated shortly after birth via endoreplication and interrupted mitosis, which persists through adulthood. The very closely related inbred mouse strains BALB/cJ and BALB/cByJ differ substantially (6.6% vs. 14.3%) in adult mononuclear CM level. This difference is the likely outcome of a single X-linked polymorphic gene that functions in a CM-nonautonomous manner, and...

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Identifiers

PMID: 32371981
DOI: 10.1038/s41598-020-64621-0
PMCID: PMC7200697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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