Article
Genome-wide association mapping and targeted loss of function studies identify Shroom3 as a driver of hyperpolyploidy and ventricular dilation.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jun 2026
Purdy Alexandra L, Bakhshian Nik Amirala, Arkatkar Anooj A, Hasan Prottoy, Flinn Michael A, Choudhury Priyanka, Wood Cheyret, Takizawa Akiko, Malloy Lynn, Tutaj Monika, Drysdale Thomas A, Bridgewater Darren, Link Brian A, Plageman Timothy F, Kwitek Anne E, Dwinell Melinda R, Saba Laura M, O'Meara Caitlin C, Patterson Michaela
Abstract excerpt
Various states of cardiomyocyte (CM) polyploidy have been associated with cardiac injury responses, including regeneration and heart failure. However, our understanding of the comprehensive mechanisms governing CM ploidy and its relationship with heart physiology is limited. To address this issue and uncover genetic regulators, we surveyed CM ploidy across a new genetic resource known as the Hybrid Rat Diversity...
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