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Heart regeneration and the cardiomyocyte cell cycle

28 Aug 2017

Abstract excerpt

Cardiovascular disease and in particular, heart failure are still main causes of death; therefore, novel therapeutic approaches are urgently needed. Loss of contractile substrate in the heart and limited regenerative capacity of cardiomyocytes are mainly responsible for the poor cardiovascular outcome. This is related to the postmitotic state of differentiated cardiomyocytes, which is partly due to their...

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PMID: 28849267
DOI: 10.1007/s00424-017-2061-4

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