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Article

Harnessing marine natural products to inhibit PAD4 triple mutant: A structure-based virtual screening approach for rheumatoid arthritis therapy.

Archives of biochemistry and biophysics - 1 Nov 2024

Panchalingam Santhiya, Jayaraman Manikandan, Jeyaraman Jeyakanthan, Kasivelu Govindaraju

Abstract excerpt

Peptidylarginine deiminase type4 (PAD4) is a pivotal pro-inflammatory protein within the human immune system, intricately involved in both inflammatory processes and immune responses. Its role extends to the generation of diverse immune cell types, including T cells, B cells, natural killer cells, and dendritic cells. PAD4 has recently garnered attention due to its association with a spectrum of inflammatory and...

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Identifiers

PMID: 39326772
DOI: 10.1016/j.abb.2024.110164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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