LncRNA EMBP1 sponges miR-454-3p to upregulate IRF1 and activate NLRP3-mediated chondrocyte pyroptosis to drive osteoarthritis progression

Abstract excerpt

BACKGROUND: Osteoarthritis (OA) is the most common degenerative joint disease worldwide. Studies have confirmed that pyroptosis is closely associated with the OA onset and progression, particularly via the classical pathway mediated by the NLRP3 inflammasome. However, the intrinsic regulatory mechanisms underlying pyroptosis in OA remain unclear. METHODS: We conducted RNA sequencing (RNA-seq) analysis on clinical...

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