Article

Targeting z-Crystallin by aspirin restores the sensitivity to cisplatin in resistant A2780 ovarian cancer cells

2024-01-25

Abstract excerpt

<h4>Purpose: </h4> Ovarian cancer is the deadliest gynaecologic malignancies worldwide. Platinum based chemotherapy is the mainstay treatment for ovarian cancer; however, frequent recurrence and chemoresistance onset in patients with advanced diseases remain a therapeutic challenge. Although mechanisms underlying the development of chemoresistance are still ambiguous, the B-cell lymphoma-2 (Bcl-2) family is closel...

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Literature Corpus work: 13717605-bc3f-5ec1-a238-81fa056843e5
DOI: 10.21203/rs.3.rs-3890267/v1

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