Article

Alpha-B-Crystallin overexpression is sufficient to promote tumorigenesis and metastasis in mice

2022-08-01

Abstract excerpt

<title>Abstract</title> <p>αB-Crystallin is a heat shock chaperone protein which binds to misfolded proteins to prevent their aggregation. It is overexpressed in a wide-variety of cancers. Previous studies using human cancer cell lines and human xenograft models have reported tumor suppressor or tumor promoter (oncogene) roles for αB-Crystallin depending on cellular context and environmental conditions. To determ...

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Literature Corpus work: 968eda05-80cd-51eb-b5f1-c102746c7285
DOI: 10.21203/rs.3.rs-1900298/v1

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