Article

The role of histone deacetylase 4 (HDAC4) in acquired cisplatin-resistant ovarian cancer

2011-01-01

Abstract excerpt

Resistance to platinum is a major problem in the treatment of ovarian cancer. Molecular profiling of isogenic ovarian cancer cell line pairs derived from tumour cells pre- and post- clinical resistance, identified that histone deacetylase 4 (HDAC4) is over-expressed in cisplatin-resistant cells relative to sensitive derivatives. HDAC4 siRNA and HDACi treatment resensitised resistant cells to cisplatin. Furthermore...

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Literature Corpus work: 5c42924c-f62d-5d48-b154-5cc82b3b2acd
DOI: 10.25560/9068

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