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Article

Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer

1 Oct 2005

Abstract excerpt

Deoxycytosine methylation within CpG islands of tumor suppressor genes plays a prominent role in the development and progression of drug-resistant ovarian cancer. Consequently, epigenetic therapies directed toward tumor suppressor demethylation/reexpression could potentially reverse malignant phenotypes and chemosensitize recalcitrant tumors. In this report, we examined the demethylating agent zebularine...

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Share to Chemotherapy-induced organ toxicity mitigation
Share to Epigenetics and DNA Methylation
Share to Histone Deacetylase Inhibitors Research

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PMID: 16227399
DOI: 10.1158/1535-7163.mct-05-0216

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