Article

A novel camptothecin derivative, ZBH-01, exhibits superior antitumor efficacy than irinotecan by regulating the cell cycle

2022-07-27

Abstract excerpt

<title>Abstract</title> <p>Irinotecan (CPT-11) is a classic chemotherapeutic agent that plays an important role in the clinical treatment of metastatic colon cancer and other malignant tumors. We previously designed a series of novel irinotecan derivatives and selected one representative, ZBH-01, to investigate its sophisticated antitumor mechanisms in colon tumor cells. Our current results showed that ZBH-01 has...

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Literature Corpus work: 25cab5c1-67fa-591a-bfe0-6e132749c119
DOI: 10.21203/rs.3.rs-1770908/v1

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