Article

Transglutaminase 2 exacerbates ovarian cancer survival by inactivating GSK3β

2025-08-13

Abstract excerpt

<title>Abstract</title> <p>Elevated expression of transglutaminase 2 (TGase 2, EC 2.3.2.13, protein-glutamine g-glutamyltransferase, gene name TGM2) is recognized as one of the most upregulated genes during epithelial-mesenchymal transition (EMT) in ovarian cancer. Despite initial complete responses to conventional chemotherapy, ovarian cancer often recurs with metastasis, posing a major clinical challenge. Drug-...

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Literature Corpus work: 032f839b-7c70-5865-a163-16591cafc19e
DOI: 10.21203/rs.3.rs-7297143/v1

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