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Article

Gene regulatory network underlying the immortalization of epithelial cells.

BMC systems biology - 16 Feb 2017

Méndez-López Luis Fernando, Davila-Velderrain Jose, Domínguez-Hüttinger Elisa, Enríquez-Olguín Christian, Martínez-García Juan Carlos, Alvarez-Buylla Elena R

Abstract excerpt

BACKGROUND: Tumorigenic transformation of human epithelial cells in vitro has been described experimentally as the potential result of spontaneous immortalization. This process is characterized by a series of cell-state transitions, in which normal epithelial cells acquire first a senescent state which is later surpassed to attain a mesenchymal stem-like phenotype with a potentially tumorigenic behavior. In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28209158
DOI: 10.1186/s12918-017-0393-5
PMCID: PMC5314717

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