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Article

Lack of Evidence for Changing Virulence of HIV-1 in North America

5 Feb 2008

Abstract excerpt

BACKGROUND: Several long-term cohort studies and in-vitro fitness assays have resulted in inconsistent reports on changes in HIV-1 virulence, including reports of decreasing, stable, and increasing virulence over the course of the AIDS pandemic. We tested the hypothesis of changing HIV-1 virulence by examining trends in prognostic clinical markers of disease progression from 1984 to 2005 among nearly 400...

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PMID: 18253479
DOI: 10.1371/journal.pone.0001525

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