Article

Long-term monitoring of inflammation in the mammalian gut using programmable commensal bacteria

2016-09-13

Abstract excerpt

Inflammation in the gut, caused by infection and autoimmunity, remains challenging to effectively detect, monitor, and treat. Here, we engineer a commensal mouse E. coli strain to record exposure to tetrathionate, a downstream product of reactive oxygen species generated during inflammation. Using these programmed bacteria to sense in situ levels we show that tetrathionate accompanies inflammation during Salmone...

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Literature Corpus work: 133c4d2a-fd24-5c6f-b78d-40dba83da2ff
DOI: 10.1101/075051

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