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Disrupted HSF1 regulation in normal and exceptional brain aging

14 Sept 2023

Abstract excerpt

Brain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either...

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PMID: 37707683
DOI: 10.1007/s10522-023-10063-w

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